À propos de ce cours
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40 notes
11 avis
Spécialisation

Cours 4 sur 7 dans le

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Niveau débutant

Niveau débutant

Heures pour terminer

Approx. 17 heures pour terminer

Recommandé : 3 hours/week...
Langues disponibles

Anglais

Sous-titres : Anglais
Spécialisation

Cours 4 sur 7 dans le

100 % en ligne

100 % en ligne

Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles

Dates limites flexibles

Réinitialisez les dates limites selon votre disponibilité.
Niveau débutant

Niveau débutant

Heures pour terminer

Approx. 17 heures pour terminer

Recommandé : 3 hours/week...
Langues disponibles

Anglais

Sous-titres : Anglais

Programme du cours : ce que vous apprendrez dans ce cours

Semaine
1
Heures pour terminer
3 heures pour terminer

Week 1: Introduction to Evolutionary Tree Construction

<p>Welcome to our class!</p><p>In this class, we will consider the following two central biological&nbsp;questions (the computational approaches needed to solve them are shown in parentheses):</p><ol><li>Weeks 1-3: Which Animal Gave Us SARS? (<i>Evolutionary tree construction</i>)</li><li>Weeks 4-5: Was <em>T. rex</em> Just a Big Chicken?&nbsp;(<em>Combinatorial Algorithms</em>)</li></ol><p>In Week 6, you will complete a Bioinformatics Application Challenge to apply evolutionary tree construction algorithms in order to determine the origin of the recent ebola outbreak in Africa.</p><p>As in previous courses, each of these two chapters is accompanied by a Bioinformatics Cartoon created by talented artist Randall Christopher and serving as a chapter header in the Specialization's bestselling <a href="http://bioinformaticsalgorithms.com" target="_blank">print companion</a>. You can find the first chapter's cartoon at the bottom of this message. What do stick bugs and bats have to do with deadly viruses? And how can bioinformatics be used to stop these viruses in their tracks? Start learning today and find out!</p><p><img src="http://bioinformaticsalgorithms.com/images/cover/evolution_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/evolution_cropped.jpg" width="528"></p>...
Reading
5 vidéos (Total 34 min), 2 lectures, 3 quiz
Video5 vidéos
The Fastest Outbreak 5 min
Transforming Distance Matrices into Evolutionary Trees 6 min
Toward an Algorithm for Distance-Based Phylogeny Construction 8 min
Additive Phylogeny 9 min
Reading2 lectures
Course Details10 min
Week 1 FAQs (Optional)
Quiz1 exercices pour s'entraîner
Week 1 Quiz15 min
Semaine
2
Heures pour terminer
3 heures pour terminer

Week 2: More Algorithms for Constructing Trees from Distance Matrices

<p>Welcome to Week 2 of class!</p> <p>Last week, we started to see how evolutionary trees can be constructed from distance matrices. &nbsp;This week, we will encounter additional algorithms for this purpose, including the neighbor-joining algorithm, which has become one of the top-ten most cited papers in all of science since its introduction three decades ago.</p>...
Reading
3 vidéos (Total 17 min), 1 lecture, 3 quiz
Video3 vidéos
Ultrametric Trees 6 min
The Neighbor-Joining Algorithm 7 min
Reading1 lectures
Week 2 FAQs (Optional)
Quiz1 exercices pour s'entraîner
Week 2 Quiz15 min
Semaine
3
Heures pour terminer
4 heures pour terminer

Week 3: Constructing Evolutionary Trees from Characters

<p>Welcome to week 3 of class!</p> <p>Over the last two weeks, we have seen several different algorithms for constructing evolutionary trees from distance matrices.</p> <p>This week, we will conclude the current chapter by considering what happens if we use properties called "characters" instead of distances. We will also see how to infer the ancestral states of organisms in an evolutionary tree, and consider whether it is possible to define an efficient algorithm for this task.</p>...
Reading
4 vidéos (Total 20 min), 1 lecture, 3 quiz
Video4 vidéos
The Small Parsimony Algorithm 8 min
The Large Parsimony Algorithm 3 min
Evolutionary Tree Reconstruction in the Modern Era 5 min
Reading1 lectures
Week 3 FAQs (Optional)
Quiz1 exercices pour s'entraîner
Week 3 Quiz15 min
Semaine
4
Heures pour terminer
1 heures pour terminer

Week 4

<p>Welcome to week 4 of the class!</p> <p>Did birds evolve from dinosaurs? Over the next two weeks, we will see how we could analyze molecular evidence in support of this theory. You can find this week's Bioinformatics Cartoon from Randall Christopher at the bottom of this E-mail. Why does the <em>T. rex&nbsp;</em>look so much like a chicken? And why is the monkey typing frantically? Keep learning to find out!</p> <p><img src="http://bioinformaticsalgorithms.com/images/cover/proteomics_cropped.jpg" title="Image: http://bioinformaticsalgorithms.com/images/cover/proteomics_cropped.jpg" width="528"></p>...
Reading
4 vidéos (Total 26 min), 1 lecture, 2 quiz
Video4 vidéos
Decoding an Ideal Spectrum 5 min
From Ideal to Real Spectra 5 min
Peptide Sequencing 7 min
Reading1 lectures
Note on This Week's Assignments10 min
Quiz1 exercices pour s'entraîner
Week 4 Quiz15 min
4.5
11 avisChevron Right

Meilleurs avis

par RGJul 20th 2017

Covers the most important algorithms for phylogenetic trees. Fascinating exam

Enseignants

Avatar

Pavel Pevzner

Professor
Department of Computer Science and Engineering
Avatar

Phillip Compeau

Visiting Researcher
Department of Computer Science & Engineering

À propos de University of California San Diego

UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory....

À propos de la Spécialisation Bioinformatics

Join Us in a Top 50 MOOC of All Time! How do we sequence and compare genomes? How do we identify the genetic basis for disease? How do we construct an evolutionary Tree of Life for all species on Earth? When you complete this Specialization, you will learn how to answer many questions in modern biology that have become inseparable from the computational approaches used to solve them. You will also obtain a toolkit of existing software resources built on these computational approaches and that are used by thousands of biologists every day in one of the fastest growing fields in science. Although this Specialization centers on computational topics, you do not need to know how to program in order to complete it. If you are interested in programming, we feature an "Honors Track" (called "hacker track" in previous runs of the course). The Honors Track allows you to implement the bioinformatics algorithms that you will encounter along the way in dozens of automatically graded coding challenges. By completing the Honors Track, you will be a bioinformatics software professional! Learn more about the Bioinformatics Specialization (including why we are wearing these crazy outfits) by watching our introductory video. You can purchase the Specialization's print companion, Bioinformatics Algorithms: An Active Learning Approach, from the textbook website. Our first course, "Finding Hidden Messages in DNA", was named a top-50 MOOC of all time by Class Central!...
Bioinformatics

Foire Aux Questions

  • Une fois que vous êtes inscrit(e) pour un Certificat, vous pouvez accéder à toutes les vidéos de cours, et à tous les quiz et exercices de programmation (le cas échéant). Vous pouvez soumettre des devoirs à examiner par vos pairs et en examiner vous-même uniquement après le début de votre session. Si vous préférez explorer le cours sans l'acheter, vous ne serez peut-être pas en mesure d'accéder à certains devoirs.

  • Lorsque vous vous inscrivez au cours, vous bénéficiez d'un accès à tous les cours de la Spécialisation, et vous obtenez un Certificat lorsque vous avez réussi. Votre Certificat électronique est alors ajouté à votre page Accomplissements. À partir de cette page, vous pouvez imprimer votre Certificat ou l'ajouter à votre profil LinkedIn. Si vous souhaitez seulement lire et visualiser le contenu du cours, vous pouvez accéder gratuitement au cours en tant qu'auditeur libre.

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