À propos de ce cours : This course introduces you to the basic biology of modern genomics and the experimental tools that we use to measure it. We'll introduce the Central Dogma of Molecular Biology and cover how next-generation sequencing can be used to measure DNA, RNA, and epigenetic patterns. You'll also get an introduction to the key concepts in computing and data science that you'll need to understand how data from next-generation sequencing experiments are generated and analyzed. This is the first course in the Genomic Data Science Specialization.
Créé par : Université Johns-Hopkins
Enseigné par : Steven Salzberg, PhD, Professor
Biomedical Engineering, Computer Science, and Biostatistics
Enseigné par : Jeff Leek, PhD, Associate Professor, Biostatistics
Bloomberg School of Public Health
| Informations de base | Cours 1 de 8 dans Genomic Data Science Specialization |
| Langue | English |
| Comment réussir | Réussissez tous les devoirs notés pour terminer le cours. |
| Notes des utilisateurs |
Programme de cours
SEMAINE 1
Overview
In this Module, you can expect to study topics of "Just enough molecular biology", "The genome", "Writing a DNA sequence", "Central dogma", "Transcription", "Translation", and "DNA structure and modifications".
8 vidéos, 2 lectures
- Reading: Syllabus
- Reading: Pre-Course Survey
- Vidéo: What Is Genomics?
- Vidéo: What Is Genomic Data Science?
- Vidéo: Just Enough Cell Biology
- Vidéo: Important Molecules in Molecular Biology
- Vidéo: The Human Genome Project
- Vidéo: Molecular Biology Structures
- Vidéo: From Genes to Phenotypes
Noté: Quiz 1: Overview and Molecular Biology
SEMAINE 2
Measurement Technology
In this module, you'll learn about polymerase chain reaction, next generation sequencing, and applications of sequencing.
3 vidéos
- Vidéo: Next Generation Sequencing
- Vidéo: Applications of Sequencing
Noté: Quiz 2: Measurement Technology
SEMAINE 3
Computing Technology
The lectures for this module cover a few basic topics in computing technology. We'll go over the foundations of computer science, algorithms, memory and data structures, efficiency, software engineering, and computational biology software.
6 vidéos
- Vidéo: Algorithms
- Vidéo: Memory and Data Structures
- Vidéo: Efficiency
- Vidéo: Software Engineering
- Vidéo: What is Computational Biology Software
Noté: Quiz 3: Computing Technology
SEMAINE 4
Data Science Technology
In this module on Data Science Technology, we'll be covering quite a lot of information about how to handle the data produced during the sequencing process. We'll cover reproducibility, analysis, statistics, question types, the central dogma of inference, analysis code, testing, prediction, variation, experimental design, confounding, power, sample size, correlation, causation, and degrees of freedom.
10 vidéos, 2 lectures
- Vidéo: What Went Wrong?
- Vidéo: The Central Dogma of Statistics
- Vidéo: Data Sharing Plans
- Vidéo: Getting Help with Statistics
- Vidéo: Plotting Your Data
- Vidéo: Sample Size and Variability
- Vidéo: Statistical Significance
- Vidéo: Multiple Testing
- Vidéo: Study Design, Batch Effects, and Confounding
- Reading: Course Project Instructions and Reading
- Reading: Post-Course Survey
Noté: Quiz 4: Data Science Technology
Noté: Course Project
FAQ
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Créateurs
Université Johns-Hopkins
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
Tarification
| Acheter le cours | |
|---|---|
| Accéder au contenu du cours | Disponible |
| Accéder au contenu noté | Disponible |
| Recevoir une Note Finale | Disponible |
| Obtenir un Certificat de Cours partageable | Disponible |
Notation et examens
Very clear lectures from experts in the field. A great introduction to online study with JHU.
It goes into great detail to prepare one for study and competency in the field.
I think this is a great introductory course to genomic data analysis. however, the primer of molecular biology and techniques could be more detailed. It also helps to have some prior knowledge in this area to really understand the details and complexities. Looking forward to the other classes though. It was refreshing to jog my memory on many of these things!
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IS
Excellent content, very helpful indeed