About this course: In Spring 2011, thousands of people in Germany were hospitalized with a deadly disease that started as food poisoning with bloody diarrhea and often led to kidney failure. It was the beginning of the deadliest outbreak in recent history, caused by a mysterious bacterial strain that we will refer to as E. coli X. Soon, German officials linked the outbreak to a restaurant in Lübeck, where nearly 20% of the patrons had developed bloody diarrhea in a single week. At this point, biologists knew that they were facing a previously unknown pathogen and that traditional methods would not suffice – computational biologists would be needed to assemble and analyze the genome of the newly emerged pathogen. To investigate the evolutionary origin and pathogenic potential of the outbreak strain, researchers started a crowdsourced research program. They released bacterial DNA sequencing data from one of a patient, which elicited a burst of analyses carried out by computational biologists on four continents. They even used GitHub for the project: https://github.com/ehec-outbreak-crowdsourced/BGI-data-analysis/wiki The 2011 German outbreak represented an early example of epidemiologists collaborating with computational biologists to stop an outbreak. In this Genome Assembly Programming Challenge, you will follow in the footsteps of the bioinformaticians investigating the outbreak by developing a program to assemble the genome of the E. coli X from millions of overlapping substrings of the E.coli X genome.
Taught by: Alexander S. Kulikov, Visiting Professor
Department of Computer Science and Engineering
Taught by: Michael Levin, Lecturer
Computer Science
Taught by: Pavel Pevzner, Professor
Department of Computer Science and Engineering
Taught by: Neil Rhodes, Adjunct Faculty
Computer Science and Engineering
| Basic Info |
Course 6 of 6 in the
Data Structures and Algorithms Specialization.
|
| Level | Advanced |
| Language | English |
| How To Pass | Pass all graded assignments to complete the course. |
| User Ratings |
Each course is like an interactive textbook, featuring pre-recorded videos, quizzes and projects.
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| Audit | Purchase Course | |
|---|---|---|
| Access to course materials | Available | Available |
| Access to graded materials | Not available | Available |
| Receive a final grade | Not available | Available |
| Earn a shareable Course Certificate | Not available | Available |
Really Challenging course, will make the mind to work.
Enjoyed taking the course, was much harder than expected and loved it anyway.
Worth the time ,effort and resources.
The course was much less guided compared to other the course but instructor mentioned it that it was on purpose for developing self learning and facing real life sitituations.
challenging
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Great challenge, requires quite a lot of time, patience and dedication. But in the end, if you eventually come through all of the trials - you will become a better programmer, for sure.
I've put 4 of 5 because of the mismatches in tasks description for the capstone project, when i had to guess, where the mismatch is, spending extra hours of my time