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Niveau intermédiaire
Approx. 95 heures pour terminer
Anglais
Sous-titres : Anglais
Certificat partageable
Obtenez un Certificat lorsque vous terminez
100 % en ligne
Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles
Réinitialisez les dates limites selon votre disponibilité.
Niveau intermédiaire
Approx. 95 heures pour terminer
Anglais
Sous-titres : Anglais

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Université Johns-Hopkins

Programme du cours : ce que vous apprendrez dans ce cours

Semaine
1

Semaine 1

75 heures pour terminer

Module 1

75 heures pour terminer
10 vidéos (Total 121 min), 3 lectures, 1 quiz
10 vidéos
Course Introduction16 min
Introduction49s
Center for Alternatives to Animal Testing4 min
Toxicology of the Fifteenth to Twentieth Centuries15 min
Toxicology for the Twenty-First Century15 min
Historical Perspective17 min
The First Report: Toxicity Testing for Assessment of Environmental Agents11 min
The Second Report: Toxicity Testing in the 21st Century: A Vision and A Strategy Vision and Its Components22 min
The Second Report: Toxicity Testing in the 21st Century: A vision and A Strategy Implementation13 min
3 lectures
useful links20 min
supporting reading material10 min
Supporting reading material10 min
1 exercice pour s'entraîner
Module 1 Quizs
Semaine
2

Semaine 2

5 heures pour terminer

Module 2

5 heures pour terminer
10 vidéos (Total 119 min), 4 lectures, 2 quiz
10 vidéos
Adverse Outcome Pathways (AOPs)10 min
Exposure-Based Chemical Prioritization13 min
ER Bioactivity Model16 min
US EPA Endocrine Disruptor Screening Program (EDSP)17 min
Modeling of Hazard and Organ Manifestation11 min
Building a Signature for Vascular Disruption10 min
Testing the Vascular Disruption Signature8 min
Virtual Tissue Model: Vascular Development12 min
Functional Vascular Development Assays16 min
4 lectures
Supporting Reading Material10 min
Useful links10 min
Supporting Reading Material10 min
Useful links10 min
1 exercice pour s'entraîner
Module 2 Quiz8 min
Semaine
3

Semaine 3

3 heures pour terminer

Module 3

3 heures pour terminer
11 vidéos (Total 126 min), 2 lectures, 1 quiz
11 vidéos
Mechanistic Toxicology and Pathway Mapping at the Basics of 21st Century Toxicology16 min
The Concept of the Human Toxome Project21 min
Concept and Tool Devlopment11 min
Progress7 min
Conclusions and Prospectives8 min
Introduction - What Is a Pathway of Toxicity, and Why Do We Need Them?6 min
Omics Technologies and High-Throughput Data11 min
Interpreting Omics Data11 min
PoT Examples and Conclusions15 min
Pathways of Toxicity and Adverse Outcome Pathways (AOPs)13 min
2 lectures
Supporting reading materials10 min
Supporting reading material10 min
1 exercice pour s'entraîner
Module 3 Quiz8 min
Semaine
4

Semaine 4

4 heures pour terminer

Module 4

4 heures pour terminer
15 vidéos (Total 148 min), 3 lectures, 2 quiz
15 vidéos
The Concept of Toxicological (Biological) Pathways, e.g., “Adverse Outcome Pathways,” Is the Basis of Predictive Toxicology5 min
Introduction to the OECD AOP Framework10 min
Building, Evaluating, and Using AOPs in Safety Decisions6 min
Online Tools Available to Everyone, Including an Online AOP Course4 min
Welcome to Module 42 min
Introduction to Read-Across18 min
Good Read-Across Practice21 min
Supporting Read-Across with Biological Data12 min
Creating a Database of Toxicity12 min
Creating an Automated Tool for Read-Across9 min
Paradigm Shift in Toxicology7 min
2D In Vitro Cell Culture8 min
3D In Vitro Cell Cultures8 min
Organ-on-a-Chip11 min
3 lectures
Supporting reading material10 min
Supporting reading material10 min
Useful links10 min
2 exercices pour s'entraîner
Module 4 Quiz8 min
Mid-term exam44 min
1 heure pour terminer

Module 5

1 heure pour terminer
6 vidéos (Total 41 min), 1 lecture, 1 quiz
6 vidéos
MicroRNA and Epigenetics4 min
Epigenetics and Environment6 min
MicroRNA: Biogenesis and Functions11 min
Role of MicroRNA in Development6 min
MicroRNA in Toxicology9 min
1 lecture
Supporting reading material10 min
1 exercice pour s'entraîner
Module 5 Quiz8 min

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