À propos de ce cours : The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors.
Les destinataires de ce cours : The topic of sleep is an ideal vehicle for teaching neuroanatomy, neurochemistry, pharmacology, physiology, and cognitive neuroscience. Based on more than 10 years of experience with the traditional classroom setting, students who do well in the course are up-to-date on basic biology, chemistry, and neuroscience.
Créé par : Université du Michigan
Enseigné par : Ralph Lydic, Ph.D., Professor Emeritus, Molecular and Integrative Physiology, Professor Emeritus, Anesthesiology
University of Michigan Medical School
Enseigné par : Helen Baghdoyan, Ph.D., Professor Emeritus, Anesthesiology, Professor Emeritus, Pharmacology, Professor of Psychiatry
University of Michigan Medical School
| Niveau | Beginner |
| Langue | English |
| Comment réussir | Réussissez tous les devoirs notés pour terminer le cours. |
| Notes des utilisateurs |
Programme de cours
SEMAINE 1
Unit 01 - Neurobiology Section: Course Introduction & Neurobiology of Sleep and Wakefulness (Part One) - (Standard Track & Honors Track)
This unit begins with a Course Overview video from Ralph Lydic, Ph.D., followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture, delivered by Helen Baghdoyan, Ph.D. PLEASE NOTE: Only the Course Overview video, and the Getting Started and Syllabus readings are required for students who have chosen to engage in the Standard Track portion of the course content. Standard track students may also bypass all content in units 2, 3, and 4, and instead move directly to unit 5 after viewing the Course Overview video.
6 vidéos, 4 lectures
- Reading: Getting Started
- Reading: Syllabus
- Vidéo: 01.01 - Course Overview - Ralph Lydic, Ph.D.
- Reading: Help Us Learn More About You!
- Reading: Lesson 2 Orientation
- Vidéo: 02.01 - Learning Points
- Vidéo: 02.02 - Defining Behavioral States
- Vidéo: 02.03 - Historical Overview: Brainstem & Forebrain
- Vidéo: 02.04 - Wake & REM: Monoamines
- Vidéo: 02.05 - Wake & REM: Acetylcholine
Noté: Did you Complete Lesson 2?
SEMAINE 2
Unit 02 - Neurobiology Section: Neurobiology of Sleep and Wakefulness (Part Two) - (Honors Track)
Unit 2 continues the lecture from Helen Baghdoyan, Ph.D. on the Neurobiology of Sleep and Wakefulness. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
5 vidéos
- Vidéo: 02.06 - Wake & REM: GABA
- Vidéo: 02.07: Wake & REM: Orexin
- Vidéo: 02.08: NREM: GABA
- Vidéo: 02.09: NREM: Adenosine
- Vidéo: 02:10: Summary
Noté: Did you complete Lesson 03?
Noté: Unit 02 Honors Track Quiz - Neurobiology of Sleep and Wakefulness
SEMAINE 3
Unit 03 - Neurobiology: Mathematical Modeling of Sleep-Wake Regulation - (Honors Track)
Unit 3 continues the Neurobiology section of the content with a lecture from Victoria Booth, Ph.D. on the Mathematical Modeling of Sleep-Wake Regulation. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
10 vidéos, 1 lecture
- Reading: Unit 03 Orientation
- Vidéo: 03.01 - Introduction to Mathematical Modeling of Sleep-Wake Regulation
- Vidéo: 03.02 - Two Process Model
- Vidéo: 03.03 - Sleep-Wake Flip-Flop Model
- Vidéo: 03.04 - Reciprocal Interaction Model
- Vidéo: 03.05 - REM Sleep Flip-Flop Model
- Vidéo: 03.06 - Features for an Ideal Model of Sleep-Wake Regulation
- Vidéo: 03.07 - Introduction to Mechanistic Models of Sleep-Wake Regulation
- Vidéo: 03.08 - Diniz Benh & Booth Model - Part I
- Vidéo: 03.09 - Diniz Benh & Booth Model - Part II
- Vidéo: 03.10 - Conclusion
Noté: Did you Complete Lesson 5?
Noté: Unit 03 Quiz - Mathematical Modeling of Sleep-Wake Regulation
SEMAINE 4
Unit 04 - Neurobiology: Molecular Biology and Genetics of Sleep - (Honors Track)
Unit 4 closes out the Neurobiology section with a lecture from Chiara Cirelli, Ph.D. on Molecular Biology and the Genetics of Sleep. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
6 vidéos
- Vidéo: 04.01 - Expression of mRNA Varies During Sleep and Wakefulness
- Vidéo: 04.02 - Wake Genes that are Associated with Energy Metabolism
- Vidéo: 04.03 - Synaptic Plasticity is Genetically Modulated
- Vidéo: 04.04 - Brain Glial Cells Influence States of Sleep and Wakefulness
- Vidéo: 04.05 - Genetic Modulation of Human Sleep Phenotypes
- Vidéo: 04.06 - Conclusion
Noté: Did you complete Lesson 7?
Noté: Unit 04 Quiz - Molecular Biology and Genetics of Sleep
SEMAINE 5
Unit 05 - Medicine: Overview of Sleep Medicine - Ronald Chervin, M.D. - (Standard Track)
Unit 5 marks the beginning of the Medicine section of the course. This unit features an overview of Sleep Medicine from Ronald Chervin, M.D.
7 vidéos, 1 lecture
- Reading: Unit 05 Orientation
- Vidéo: 05.01 - Introduction - Overview of Sleep Medicine
- Vidéo: 05.02 - Clinical Approach to Sleep Disorders
- Vidéo: 05.03 - Polysomnography
- Vidéo: 05.04 - Classification of Sleep Disorders
- Vidéo: 05.05 - Obstructive Sleep Apnea
- Vidéo: 05.06 - Testing for Obstructive Sleep Apnea
- Vidéo: 05.07 - Treatment for Obstructive Sleep Apnea, and Concluding Thoughts
Noté: Unit 05 Quiz- Overview of Sleep Medicine
SEMAINE 6
Unit 06 - Medicine: Disordered Sleep and Breathing Alters Cardiovascular Health - (Standard Track)
Unit 6 continues the Medicine section of the course, featuring a lecture from Helena Schotland, M.D. exploring how Disordered Sleep and Breathing may alter Cardiovascular Health.
3 vidéos, 1 lecture
- Reading: Unit 06 Orientation
- Vidéo: 06.01- Impact of Disordered Sleep and Breathing on Cardiovascular Health (Part 1)
- Vidéo: 06.02 - Impact of Disordered Sleep and Breathing on Cardiovascular Health (Part 2)
- Vidéo: 06.03 - Outcomes of CPAP Therapy and Conclusions
Noté: Unit 06 Quiz - Disordered Sleep and Breathing Alters Cardiovascular Health
SEMAINE 7
Unit 07 - Medicine: Sleep and Psychiatric Disorders - (Standard Track)
Unit 7 further continues the Medicine section of the course with a lecture on the relationship of Sleep and Psychiatric Disorders from Eric Nofzinger, M.D
8 vidéos, 1 lecture
- Reading: Unit 07 Orientation
- Vidéo: 07.01 - Introduction - Sleep and Psychiatric Disorders
- Vidéo: 07.02 - What Goes to Sleep?
- Vidéo: 07.03 - Sleep Alterations Associated with Specific Psychiatric Disorders
- Vidéo: 07.04 - Bipolar Disorder and Schizophrenia
- Vidéo: 07.05 - Anxiety Disorders
- Vidéo: 07.06 - Substance Use Disorders
- Vidéo: 07.07 - Insomnia
- Vidéo: 07.08 - Interventions for Insomnia
Noté: Unit 07 Quiz - Sleep and Psychiatric Disorders
SEMAINE 8
Unit 08 - Medicine: Insomnia: Causes and Consequences - (Standard Track)
Unit 8 further continues the Medicine section of the course with a lecture from Christopher Drake, Ph.D. on the causes and consequences of Insomnia.
4 vidéos, 1 lecture
- Reading: Unit 08 Orientation
- Vidéo: 08.01 - Insomnia: Causes and Consequences
- Vidéo: 08.02 - Consequences of Insomnia
- Vidéo: 08.03 - Causes of Insomnia
- Vidéo: 08.04 - Insomnia and its Relation to Hyperarousal
Noté: Unit 08 Quiz - Insomnia: Causes and Consequences
SEMAINE 9
Unit 09 - Medicine: Treatments for Insomnia - (Standard Track)
Unit 9 further continues the Medicine section of the course with a lecture from J. Todd Arendt, Ph.D. on the range of available treatments for Insomnia.
9 vidéos
- Vidéo: 09.01 - Behavioral and Pharmacological Treatments for Insomnia
- Vidéo: 09.02 - Treatment Options for Insomnia
- Vidéo: 09.03 - BzRA Hypnotics
- Vidéo: 09.04 - Abuse Liability of Hypnotic Agents
- Vidéo: 09.05 - Pharmacological Treatments for Insomnia
- Vidéo: 09.06 - Nonpharmacological Treatments for Insomnia
- Vidéo: 09.07 - How CBT-I Works
- Vidéo: 09.08 - Pharmacological Treatments for Insomnia Part III
- Vidéo: 09.09 - Summary
Noté: Unit 09 Quiz - Treatments for Insomnia
SEMAINE 10
Unit 10 - Medicine: Sleep and Anesthesia - (Standard Track)
Unit 10 brings the Medicine section of the course to a close with a lecture on Sleep and Anesthesia delivered by George Mashour, M.D.
3 vidéos
- Vidéo: 10.01 - Sleep and Anesthesia: Shared Phenotype and Shared Mechanism?
- Vidéo: 10.02 - Sleep and Anesthesia: Shared Function?
- Vidéo: 10.03 - Summary
Noté: Unit 10 Quiz - Sleep and Anesthesia
SEMAINE 11
Unit 11 - Society: Circadian Rhythms, Sleep, and Health - (Standard Track)
Unit 11 kicks off the Society section of the course with a lecture on Circadian Rhythms, Sleep, and Health from Theresa Lee, Ph.D.
5 vidéos, 1 lecture
- Reading: Unit 11 Orientation
- Vidéo: 11.01 - Why Sleep is Important
- Vidéo: 11.02 - Sleep Occurs as a Circadian Rhythm
- Vidéo: 11.03 - Changes in Sleep Rhythms Across the Lifespan (Part 1)
- Vidéo: 11.04 - Changes in Sleep Rhythms Across the Lifespan (Part 2)
- Vidéo: 11.05 - Circadian Rhythms and Sleep Hygiene
Noté: Unit 11 Quiz - Circadian Rhythms, Sleep, and Health
SEMAINE 12
Unit 12 - Society: Daytime Sleepiness and Sleep Need - Thomas Roth, Ph.D. (Standard Track)
Unit 12 wraps up the final section of the course and the Society section of the content with a lecture on Daytime Sleepiness and Sleep Need by Thomas Roth, Ph.D.
4 vidéos, 3 lectures
- Reading: Unit 12 Orientation
- Vidéo: 12.01 - Brain Basis of Daytime Sleepiness
- Vidéo: 12.02 - How is Sleepiness Measured?
- Vidéo: 12.03 - How Many People in our Society are Sleepy?
- Vidéo: 12.04 - What are the Causes of Daytime Sleepiness?
- Reading: Farewell for Now
- Reading: Post-Course Survey
Noté: Unit 12 Quiz - Daytime Sleepiness and Sleep Need
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Université du Michigan
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Notation et examens
I thoroughly enjoyed this course and look forward to continuing my education on the subject.
interesting course. However, it did not, another sleep disorder called Klein Levin syndrome which disrupts the thalamus in the brain that controls sleep. This causes the sufferer to sleep for months at a time or long extended period of time, causing disturbing sleep, increased appetite and an inability to wake up properly.
great
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Very good course! I liked it a lot not only on professional perspective, but also personally to understand the importance of a good sleep and how everything is related.