Sleep: Neurobiology, Medicine, and Society
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Sleep: Neurobiology, Medicine, and Society
University of Michigan
À propos de ce cours
4.8
42 ratings
The objective of this course is to give students the most up-to-date information on the biological, personal, and societal relevance of sleep. Personal relevance is emphasized by the fact that the single best predictor of daytime performance is the quality of the previous night's sleep. The brain actively generates sleep, and the first section of the course is an overview of the neurobiological basis of sleep control. The course provides cellular-level understanding of how sleep deprivation, jet lag, and substances such as alcohol, ,caffeine, and nicotine alter sleep and wakefulness. The second section of the course covers sleep-dependent changes in physiology and sleep disorders medicine. Particular emphasis will be placed on disorders of excessive sleepiness, insomnia, and sleep-dependent changes in autonomic control. Chronic sleep deprivation impairs immune function and may promote obesity. Deaths due to all causes are most frequent between 4:00 and 6:00 a.m., and this second section of the class highlights the relevance of sleep for preventive medicine. The societal relevance of sleep will be considered in the final section of the class. In an increasingly complex and technologically oriented society, operator-error by one individual can have a disastrous negative impact on public health and safety. Fatigue-related performance decrements are known to have contributed as causal factors to nuclear power plant failures, transportation disasters, and medical errors.
Programme du cours : ce que vous apprendrez dans ce cours
1
Section
Unit 01 - Neurobiology Section: Course Introduction & Neurobiology of Sleep and Wakefulness (Part One) - (Standard Track & Honors Track)
This unit begins with a Course Overview video from Ralph Lydic, Ph.D., followed by the first portion of the Neurobiology of Sleep and Wakefulness lecture, delivered by Helen Baghdoyan, Ph.D. PLEASE NOTE: Only the Course Overview video, and the Getting Started and Syllabus readings are required for students who have chosen to engage in the Standard Track portion of the course content. Standard track students may also bypass all content in units 2, 3, and 4, and instead move directly to unit 5 after viewing the Course Overview video.
6 vidéos (Total 93 min), 4 lectures, 1 quiz
6 vidéos
02.01 - Learning Points14 min
02.02 - Defining Behavioral States8 min
02.03 - Historical Overview: Brainstem & Forebrain17 min
02.04 - Wake & REM: Monoamines17 min
02.05 - Wake & REM: Acetylcholine17 min
4 lectures
Getting Started10 min
Syllabus10 min
Help Us Learn More About You!10 min
Lesson 2 Orientation10 min
1 exercice pour s'entraîner
Did you Complete Lesson 2?2 min
2
Section
Unit 02 - Neurobiology Section: Neurobiology of Sleep and Wakefulness (Part Two) - (Honors Track)
Unit 2 continues the lecture from Helen Baghdoyan, Ph.D. on the Neurobiology of Sleep and Wakefulness. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
5 vidéos (Total 73 min), 2 quiz
5 vidéos
02.06 - Wake & REM: GABA16 min
02.07: Wake & REM: Orexin17 min
02.08: NREM: GABA14 min
02.09: NREM: Adenosine 11 min
02:10: Summary12 min
2 exercices pour s'entraîner
Did you complete Lesson 03?2 min
Unit 02 Honors Track Quiz - Neurobiology of Sleep and Wakefulness30 min
3
Section
Unit 03 - Neurobiology: Mathematical Modeling of Sleep-Wake Regulation - (Honors Track)
Unit 3 continues the Neurobiology section of the content with a lecture from Victoria Booth, Ph.D. on the Mathematical Modeling of Sleep-Wake Regulation. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
10 vidéos (Total 67 min), 1 lecture, 2 quiz
10 vidéos
03.02 - Two Process Model 5 min
03.03 - Sleep-Wake Flip-Flop Model5 min
03.04 - Reciprocal Interaction Model 12 min
03.05 - REM Sleep Flip-Flop Model4 min
03.06 - Features for an Ideal Model of Sleep-Wake Regulation7 min
03.07 - Introduction to Mechanistic Models of Sleep-Wake Regulation 3 min
03.08 - Diniz Benh & Booth Model - Part I9 min
03.09 - Diniz Benh & Booth Model - Part II 14 min
03.10 - Conclusion 1 min
1 lecture
Unit 03 Orientation10 min
2 exercices pour s'entraîner
Did you Complete Lesson 5?2 min
Unit 03 Quiz - Mathematical Modeling of Sleep-Wake Regulation10 min
4
Section
Unit 04 - Neurobiology: Molecular Biology and Genetics of Sleep - (Honors Track)
Unit 4 closes out the Neurobiology section with a lecture from Chiara Cirelli, Ph.D. on Molecular Biology and the Genetics of Sleep. PLEASE NOTE: This content is only required for students who have chosen to pursue the Honors Track certification.
6 vidéos (Total 52 min), 2 quiz
6 vidéos
04.02 - Wake Genes that are Associated with Energy Metabolism 7 min
04.03 - Synaptic Plasticity is Genetically Modulated 7 min
04.04 - Brain Glial Cells Influence States of Sleep and Wakefulness 9 min
04.05 - Genetic Modulation of Human Sleep Phenotypes 8 min
04.06 - Conclusion 11 min
2 exercices pour s'entraîner
Did you complete Lesson 7?2 min
Unit 04 Quiz - Molecular Biology and Genetics of Sleep10 min
4.8
Meilleurs avis
par JQ•Jan 3rd 2018
Excellent course! A great review on stuff I should have remembered but of course have forgotten as I've aged. My thanks to those organizing and teaching the course! Dr Quincy
par DF•Feb 19th 2018
I thoroughly enjoyed this course and look forward to continuing my education on the subject.
Enseignants
Ralph Lydic, Ph.D.
Professor Emeritus, Molecular and Integrative Physiology, Professor Emeritus, AnesthesiologyUniversity of Michigan Medical School
Helen Baghdoyan, Ph.D.
Professor Emeritus, Anesthesiology, Professor Emeritus, Pharmacology, Professor of PsychiatryUniversity of Michigan Medical School
À propos de University of Michigan
The mission of the University of Michigan is to serve the people of Michigan and the world through preeminence in creating, communicating, preserving and applying knowledge, art, and academic values, and in developing leaders and citizens who will challenge the present and enrich the future.
Foire Aux Questions
When will I have access to the lectures and assignments?
Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.
What will I get if I purchase the Certificate?
When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
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Is financial aid available?
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