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38 avis
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Sous-titres : Anglais
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100 % en ligne

Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles

Dates limites flexibles

Réinitialisez les dates limites selon votre disponibilité.
Niveau débutant

Niveau débutant

Heures pour terminer

Approx. 13 heures pour terminer

Recommandé : 6 hours/week...
Langues disponibles

Anglais

Sous-titres : Anglais

Programme du cours : ce que vous apprendrez dans ce cours

Semaine
1
Heures pour terminer
2 heures pour terminer

Enzymes, Enzyme Discovery and Engineering

Enzyme catalysts are central to life. They are the vehicles for delivering innovative bioscience solutions to chemicals manufacture, drug discovery, therapeutics and bioprocessing. They are the key enablers in the white biotechnology revolution, providing essential components in the new science of 'synthetic biology', offering new routes to biofuels, bulk and commodity chemicals and novel therapeutics. ...
Reading
8 vidéos (Total 61 min), 2 lectures, 1 quiz
Video8 vidéos
Introduction from Nigel Scrutton38s
Overview and introduction9 min
How do enzymes work?15 min
How do we discover enzymes for application in biotechnology?5 min
How can we study and characterise the catalytic activity of enzymes?7 min
Engineering Enzymes I: Directed Evolution8 min
Engineering Enzymes II: Rational Design of Biocatalysts11 min
Reading2 lectures
Pre Course Survey and Course Credits10 min
Glossary10 min
Quiz1 exercice pour s'entraîner
Enzymes, Enzyme Discovery and Engineering22 min
Semaine
2
Heures pour terminer
2 heures pour terminer

Methods in Systems and Synthetic Biology

Recent advances in our ability to read and write genome sequences on a large scale have led to an ambitious vision for a new generation of biotechnology, often referred to as Synthetic Biology. Synthetic Biology aims at turning biology into an engineering discipline, in which organism engineers use computational tools to design biological systems with novel valuable functionalities, which are then built using advanced high-throughput genetic engineering, and tested by rapid screening technologies that collect diagnostic molecular profiles to drive improved designs in an iterative design-build-test cycle. This module will introduce the engineering concepts that inform Synthetic Biology and the cutting-edge technologies that underlie our dramatically increasing ability to construct living systems with custom-made functionalities. All stages of the design-build-test cycle for novel biosystems will be discussed, with a special focus on their integration in a unified bioengineering platform. Examples will focus on the application of Synthetic Biology as an enabling technology for the bioindustry, especially for the improved microbial production of high-value chemicals and drugs. A section on responsible research and innovation will explore the transformative potential of this innovative technology within a broader socio-economic context, creating awareness of the ethical and political implications of research in this field....
Reading
9 vidéos (Total 61 min), 2 lectures, 1 quiz
Video9 vidéos
Introduction to Synthetic Biology: Visions for Biotechnology 2.06 min
Designing biological systems: Computational modelling and systems biology9 min
Building biological systems I: Genome synthesis and genome editing9 min
Controlling and engineering pathways in Synthetic Biology9 min
Testing Biological Systems Biological debugging using metabolomics8 min
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics I5 min
Deploying biological systems: Perspectives on Responsible Research & Innovation and bioethics II6 min
Conclusions and Outlook Systems and Synthetic Biology6 min
Reading2 lectures
Glossary10 min
Systems and Synthetic Biology10 min
Quiz1 exercice pour s'entraîner
Methods in Systems and Synthetic Biology22 min
Semaine
3
Heures pour terminer
2 heures pour terminer

Biochemical and Bioprocess Engineering

Biochemical and bioprocess engineering is concerned with the design of processes which involve biological transformations to manufacture a range of bio-based chemicals, biopharmaceuticals and biofuels. Through applying knowledge of process constraints, which are usually described mathematically, biochemical engineers are able to design a series of integrated process steps or “unit operations” which together make up a bioprocess. This module will give an appreciation of the key role biochemical engineering has in translating discoveries coming from life sciences and synthetic biology, such as improved microbial platforms for product expression, into economically viable full scale production processes. Key engineering concepts and the problem solving approach required for the design of bioprocesses will be taught by a group of biochemical engineers from The University of Manchester, University College London and Technical University of Denmark....
Reading
8 vidéos (Total 90 min), 1 quiz
Video8 vidéos
Introduction from James Lawrence and Michael Sulu45s
Introduction to Biochemical and Bioprocess Engineering12 min
Microbial fermentation processes and bioreactor design10 min
Biocatalysis and enzymatic processes24 min
Recovery and purification of small molecules11 min
Recovery and purification of large molecules9 min
Process economics and scale-up19 min
Quiz1 exercice pour s'entraîner
Biochemical and Bioprocess Engineering24 min
Semaine
4
Heures pour terminer
2 heures pour terminer

Pharmaceuticals and Fine Chemicals

This module looks at the production of pharmaceuticals and fine chemicals using biocatalysis. Specifically, we will look at isolated biocatalytic transformations using isolated enzymes or whole cells as catalysts to manufacture commercially important products including pharmaceuticals, industrial monomers and personal care products. This module will be delivered by Dr Andy Wells of CHEM21, Europe’s largest public-private partnership dedicated to the development of manufacturing sustainable pharmaceuticals led by The University of Manchester and the pharmaceutical company GlaxoSmithKline. Dr Wells, alongside Dr Tom Dugmore of The University of York, will look at six industrial examples of biocatalytic reactions involving six different enzyme transformations. Each example will look at the product, manufacturing route, mechanism of the enzyme reaction and some of the sustainability drivers and metrics for adopting IB as part of the manufacturing route. Over the six examples, a number of key attributes of enzyme catalysed processes that need to be considered for successful scale-up will be examined. These include choice of free enzyme or whole cell catalyst, co-factors and co-factor recycling, multi-phase reactions, enzyme stability and throughput. Each example will have a number of references to the primary literature covering the product and enzyme type for further learning outside of the module....
Reading
7 vidéos (Total 66 min), 2 lectures, 1 quiz
Video7 vidéos
Industrial Example 1: Hydrolases11 min
Industrial Example 2: Transaminase11 min
Industrial Example 3: DERA Aldolase10 min
Industrial Example 4: Alcohol Dehydrogenases12 min
Industrial Example 5: Nitrile Hydratases8 min
Industrial Example 6: Amino Acid Oxidases9 min
Reading2 lectures
CHEM2110 min
References and Further Reading10 min
Quiz1 exercice pour s'entraîner
Pharmaceuticals and Fine Chemicals24 min

Enseignants

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Prof. Nicholas Turner

Deputy Director
Manchester Institute of Biotechnology
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Prof. Nigel Scrutton

Director
Manchester Institute of Biotechnology

À propos de University of Manchester

Tracing its roots back to 1824, the University of Manchester is home to almost 40,000 students. The University has three Nobel laureates among its current staff – more than any other British university - and a total of 25 Nobel laureates have come from our past and present students and staff. We have three main goals: to undertake world-class research; to deliver an outstanding learning and student experience; and to be socially responsible....

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