While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics.
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Le contrôle épigénétique de l'expression des gènes
Université de MelbourneÀ propos de ce cours
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Résultats de carrière des étudiants
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Approx. 17 heures pour terminer
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Compétences que vous acquerrez
CancerMolecular BiologyCancer EpigeneticsDna Methylation
Résultats de carrière des étudiants
25%
ont commencé une nouvelle carrière après avoir terminé ce cours
27%
ont bénéficié d'un avantage concret dans leur carrières grâce à ce cours
Certificat partageable
Obtenez un Certificat lorsque vous terminez
100 % en ligne
Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles
Réinitialisez les dates limites selon votre disponibilité.
Approx. 17 heures pour terminer
Anglais
Sous-titres : Arabe, Français, Portugais (européen), Italien, Vietnamien, Allemand, Russe, Anglais, Espagnol
Offert par
Université de Melbourne
The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University.
Programme du cours : ce que vous apprendrez dans ce cours
2 heures pour terminer
Week 1 - Introduction to Epigenetic Control
An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability.
2 heures pour terminer
7 vidéos (Total 65 min), 5 lectures, 1 quiz
2 heures pour terminer
Week 2 - Epigenetic Modifications and Organisation of the Nucleus
We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course.
2 heures pour terminer
9 vidéos (Total 90 min), 1 lecture, 1 quiz
3 heures pour terminer
Week 3 - Dosage Compensation
X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms.
3 heures pour terminer
12 vidéos (Total 113 min), 1 lecture, 1 quiz
2 heures pour terminer
Week 4 - Genomic Imprinting and Epigenetic Reprogramming
We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth.
2 heures pour terminer
6 vidéos (Total 68 min), 1 lecture, 1 quiz
Avis
Meilleurs avis pour LE CONTRÔLE ÉPIGÉNÉTIQUE DE L'EXPRESSION DES GÈNES
par MM1 oct. 2018
This was an excellent course. All the material was well presented and the explanation of the sometimes complex subject matter was clear and understandable. Thank you for an great learning experience.
par GK19 mai 2020
This course was new to me. All the concepts were explained in a very simplified manner. I am very happy to have done this course and find it a very interesting field to take upm in my future career.
par CY9 mai 2020
Very clear explanation of the concepts and details. I would say it is a difficult course for students from engineering background, even having some bioinfomatics and oncology courses background
par DS24 août 2018
This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!
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