À propos de ce cours
4.8
53 notes
13 avis
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Niveau intermédiaire

Niveau intermédiaire

Heures pour terminer

Approx. 9 heures pour terminer

Recommandé : 6 hours/week...
Langues disponibles

Anglais

Sous-titres : Anglais
100 % en ligne

100 % en ligne

Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles

Dates limites flexibles

Réinitialisez les dates limites selon votre disponibilité.
Niveau intermédiaire

Niveau intermédiaire

Heures pour terminer

Approx. 9 heures pour terminer

Recommandé : 6 hours/week...
Langues disponibles

Anglais

Sous-titres : Anglais

Programme du cours : ce que vous apprendrez dans ce cours

Semaine
1
Heures pour terminer
3 heures pour terminer

Cracking the Genetic Code

In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)...
Reading
7 vidéos (Total 45 min), 4 lectures, 6 quiz
Video7 vidéos
How to Speak DNA4 min
Cracking the Genetic Code4 min
The Building Blocks of DNA5 min
Packing it all in!6 min
Summing Up1 min
The Double Helix16 min
Reading4 lectures
Timeline of DNA Discoveries10 min
Behind the Picture: Photo 51 (interview)10 min
(Not Really) The Last Word about DNA (video)10 min
Biochemistry: The Operating System of Life (video)10 min
Quiz6 exercices pour s'entraîner
How to Speak DNA6 min
Cracking the Genetic Code6 min
The Building Blocks of DNA8 min
Packing it all in!6 min
DNA Word Search2 min
Cracking the Genetic Code22 min
Semaine
2
Heures pour terminer
3 heures pour terminer

Getting the Message Across: Transcription, Translation, and Replication

We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!...
Reading
8 vidéos (Total 52 min), 4 lectures, 9 quiz
Video8 vidéos
Stop copying me! DNA Replication6 min
Central Dogma, Part I: Transcription8 min
Central Dogma, Part II: Translation7 min
Practical DNA: Polymerase Chain Reaction (PCR)8 min
Practical DNA: Gel Electrophoresis7 min
Summing Up3 min
DNA Replication3 min
Reading4 lectures
The Case of the Silenced Scientist10 min
Labster: Crime Scene Investigation10 min
TED Talk: Drew Barry - Animations of Unseeable Biology (video)10 min
Protein Data Bank10 min
Quiz9 exercices pour s'entraîner
The Scene of the Crime4 min
Stop copying me! DNA Replication4 min
Central Dogma, Pt 1: Transcription8 min
Central Dogma, Pt 2: Translation6 min
Decipher the Secret Message2 min
Breaking the Code (aka Game of Codons)4 min
Polymerase Chain Reaction (PCR)4 min
Gel Electrophoresis6 min
Getting the Message Across16 min
Semaine
3
Heures pour terminer
3 heures pour terminer

Manipulating DNA

In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media....
Reading
8 vidéos (Total 46 min), 5 lectures, 7 quiz
Video8 vidéos
Slice and Dice: Restriction Enzymes10 min
Lights, Camera, Transformations6 min
Mutations, Mutations, Mutations!6 min
From Bananas to Papayas: Genetically Modified Organisms (GMOs)9 min
Summing Up4 min
Genetic Engineering1 min
Sickle Cell Anemia59s
Reading5 lectures
Labster: Molecular Cloning Simulation10 min
Creating Dolly (video)10 min
Genetic Engineering and Working with DNA (video)10 min
How did they make insulin from recombinant DNA? (article)10 min
Massive Review Reveals Consensus on GMO Safety (article)10 min
Quiz7 exercices pour s'entraîner
Freaky Fruit: Manipulating DNA6 min
Slice and Dice: Restriction Enzymes6 min
Lights, Camera, Transformations6 min
Mutations, mutations, mutations6 min
From Papayas to Bananas: Genetically Modified Organisms (GMOs)6 min
Help Felicia design a blue tomato!8 min
Manipulating DNA16 min
Semaine
4
Heures pour terminer
3 heures pour terminer

DNA and Me

What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA....
Reading
9 vidéos (Total 45 min), 7 lectures, 6 quiz
Video9 vidéos
Sanger Sequencing3 min
The Human Genome Project5 min
Mammoths, Mummies, and Microbes: Ancient DNA10 min
Me and My Family Tree8 min
DNA and My Health5 min
That's a wrap!5 min
Sanger Sequencing51s
Human Genome Sequencing1 min
Reading7 lectures
Labster: Next Generation Sequencing Simulation10 min
Cracking the Code of Life (video)10 min
Iceman Murder Mystery (video)10 min
Personal DNA Testing (video)10 min
My Career in Genomics: Antibiotic Resistance (video)10 min
My Career in Genomics: Cancer Biology (video)10 min
My Career in Genomics: Evolution (video)10 min
Quiz6 exercices pour s'entraîner
DNA: Our Genetic Blueprint2 min
Sanger Sequencing8 min
Me and My Family Tree4 min
DNA and My Health2 min
DNA and Me18 min
Scientists Complete First Chapter of Book of Life With Decoding of First Human Chromosome (article)4 min

Enseignants

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Caitlin Mullarkey

Assistant Professor
Health Sciences
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Felicia Vulcu

Assistant Professor
Biochemistry and Biomedical Sciences

À propos de McMaster University

Founded in 1887, McMaster University is committed to creativity, innovation, and excellence by inspiring critical thinking, personal growth, and a passion for learning. Ranked amongst the Top 100 universities in the world, McMaster pioneered a learner-centred, problem-based, interdisciplinary approach to learning that is now known worldwide as the “McMaster Model”. ...

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