About this course: Evidence forms the basis of modern medicine. Clinical research provides us with this evidence, guiding health professionals towards solutions to problems that they face in daily practice. Transferring existing problems in medical practice to a research setting is a challenging process that requires careful consideration. The practice of clinical epidemiology aims to address this through the application of established approaches for research in human populations, while at all times focussing on the problem at hand from a clinical perspective. This course teaches the principles and practice of clinical epidemiology, drawing on real problems faced by medical professionals and elaborating on existing examples of clinical research. Medical researchers will lean how to translate real clinical problems into tangible research questions for investigation, gaining insight into some of the most important considerations when designing an epidemiological study along the way. Core concepts will be introduced along four key themes: diagnosis, prognosis, treatment and etiology. Followers of this course will develop their understanding of the topics addressed through lectures from experts, peer interaction and review assignments.
Created by: Utrecht University
Taught by: Diederick E. Grobbee, Professor
Clinical Epidemiology
Taught by: Arno W. Hoes, Professor
Clinical Epidemiology
| Level | Intermediate |
| Commitment | 7 weeks of study, 1-3 hours/week |
| Language | English |
| How To Pass | Pass all graded assignments to complete the course. |
| User Ratings |
Syllabus
WEEK 1
About the course
Welcome! Here you will find general information about the course. The learning objectives, the structure, the format and the requirements of completion will be presented to you.
6 readings
- Reading: Welcome to the Course!
- Discussion Prompt: Introduce Yourself!
- Reading: Introduction
- Reading: Course Syllabus
- Reading: Book: 'Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research'
- Reading: Short Survey
- Reading: Credits
WEEK 2
Introduction to Epidemiology
The course will kick off with a brief introduction to some of the key concepts in epidemiological research. We will warm up with two introductory lectures, followed by a small by assignment, before diving further into the field of epidemiology from a clinical context.
4 videos
- Video: An Introduction
- Video: Core Concepts
- Video: Defining Your Research
- Video: A Multi-Level Research Problem
Graded: Examples of a Clinical Problem
Graded: Introduction to Epidemiology
WEEK 3
Diagnostic Research
This week we begin at the start of the DEPTh model: Diagnosis and diagnostic research. Through a series of lectures, you will come across familiar challenges in the area of diagnosis and discover how these problems can be addressed by clinical research.
4 videos
- Video: An Introduction to Diagnostic Research
- Video: Core Concepts in Diagnostic Research
- Video: Designing a Diagnostic Study
- Video: Case Study: A Diagnostic Rule for Deep Vein Thrombosis in Primary Care
Graded: Example of a Diagnostic Study
Graded: Reference Standard
Graded: Diagnostic Research
WEEK 4
Prognostic Research
This week you will be introduced to the challenges of evidence-based prognostication: how can we best predict the course of a patient's health? You will learn this week how this kind of question can be addressed through epidemiological research, becoming familiar with how prognostic tools can be developed for use in guiding clinical decisions.
4 videos, 1 reading, 1 practice quiz
- Video: An Introduction to Prognostic Research
- Practice Quiz: Examples of a Prognostic Study
- Video: Designing a Prognostic Study
- Reading: Feedback
- Video: Developing and Validating a Prediction Rule
- Video: Case Study: Developing a Prediction Rule for 10-year Cardiovascular Disease Risk
Graded: Study Design of Data Collection
Graded: Prognostic Research
WEEK 5
Intervention Research
In our final week of lectures, you will step into the world of intervention research, exploring the "Therapeutic" branch of the DEPTh model. We will focus on the study of intended and unintended effects, exploring a new kind of study design: the randomized controlled trial.
4 videos, 1 reading
- Video: An Introduction to Intervention Research
- Video: Intended Effects
- Video: Unintended Effects
- Video: Case Study: Pneumococcal Vaccination in Adults
- Reading: Preparing the Debate
Graded: Intervention Research
WEEK 6
The Online Debate
The task this week is in the form of an online debate in which you will study an existing piece of clinical research and contribute to a discussion of this research, forming both an objective assessment and using that to develop your own opinions.
2 items
- Discussion Prompt: Discuss the Debate
Graded: The Online Debate
WEEK 7
Exam and Conclusion
This is final assessment in the course: a quiz of 30 multiple choice questions that aim to test how well you can apply the knowledge you have gained throughout the course. Good luck!
1 reading
- Discussion Prompt: Farewells
- Reading: Final Survey
Graded: Clinical Epidemiology
FAQs
How It Works
Coursework
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Creators
Utrecht University
Utrecht University is a research university comprising seven faculties which collectively span the entire academic spectrum in teaching and research. Founded in 1636, the University is now a modern, leading institute enjoying a growing international reputation. In the Shanghai Ranking, Utrecht University ranks 1st in the Netherlands, 17th in Europe and 56th worldwide. The research focuses on four main strategic themes: Dynamics of Youth, Institutions for Open Societies, Life Sciences and Sustainability. Our motto is: Bright minds, better future.
Ratings and Reviews
Great courses!!
The course provide a good introduction to clinical epidemiology, but additional reading is required.
Fun and interesting course! Thanks so much. Dr Quincy
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Excellent course!