And the whole point is, what you want to be able to say is, that somehow or another that your direct cost savings or the productivity increase that your drug produces. Or the improvement in quality of life that your drug produces is greater than the money that you're asking for your product. And you would love to have a product in which you, you could say all three of these. Eh, but not necessarily going to happen. You would be happy with one of these, probably. It's, it's great if you can say all three of these. Okay. So to, to make this sort of statements there are several types of pharmacoeconomic analyses which I'm just going to show you so that you, you know these terms. This is a table, as you go down, there's different analyses types. The, it's all, except for the top one it's just sort of a cost of illness. Okay. They're all a cost over a denominator. So, cost minimization is cost over an equal denominator that, the effectiveness of both th, of intervention is the same, so all you have to do is look at the cost. Cost effectiveness, which you see most, if cost over some natural units like the number of patients cured, the number of, the percent with symptoms reduced. If some sort of natural medical unit on the denominator. Cost benefits, you've gotta take that denominator and say okay if it was number of lives saved, I've gotta turn that into a dollar amount. So now I've gotta put a dollar amount on those lives. And you're probably going to argue with me of how I put that dollar amount on there. And the last one is the one I just alluded to is cost utility analysis. It's cost over QALY's or quality adjusted life years. And you should probably argue with me maybe not on the length of life, I might have measured that but how did I assign the quality of life portion to that? So as you go down the table, the methods get much more complicated. And the other thing that happens is the uncertainty gets greater. Because it's, it's not as clear, the methods are not as clear at the bottom of the table. But you'll see all these types of analyses as part of pharmacoeconomic analyses. I'll show you how you get the cost effectiveness to cos, cost utility. So here's a drug, drug A cost $80. Obviously it's not a real drug. 60% of people are cured. Drug B costs $120. 80% are cured. So it costs more but I buy more for it, right. So but this is where a tradeoff is needed. Okay, so I'm going to do my tradeoff. I'm going to do a cost effective analyses, k, CEA. I take my $80 and divide it by my 60% cured and I, I find out that it costs me $133 per cured patient for drug A. Same thing for drug B cost me $150 per cured patient. But what I really want to know is the incremental costs versus incremental benefits. So I subtract my $80 from the $120. The difference in the cost, the difference in the effectiveness. And I find out really it's costing me $200 more per additional cured patient to use B, okay. And so that's in naturals units now is $200 a lot? Is it too much? Is it too little? Is that a good deal? From what I've told you. You don't know. But for any of these things you really need some benchmarks. You, you need something to tell you whether $200 is good or bad. And there are different benchmarks out there in the literature and in your group that you might be comparing to, your other products. They might already have something that's, oh well, they're only $100 per different cure. So you have to have something to compare it to. If I want to change this to a cost benefit analysis I take my $80 drug but I've gotta put the dollar value on the 60% of patients that are cured and so I'm going to tell you that's $1,000 per year. That's the value. So my cost benefit is the 60% times 1,000. It's 80 every 600, and now I'm looking at $0.13 cost per benefit, versus $0.15 cost per benefit. That doesn't a make much sense to me cost per benefit although we call it a cost benefit. You really kind of want to see what's the benefit I'm getting for the cost. If turn them upside down and in this in it's much easier to interpret. I'm getting $7.50 for every dollar I spend on drug A. But I'm only $6.70 for every dollar I spend on drug B. So it's just different ways to kind of look at the analyses. Okay now I've put, I've done cost benefits. Now if I want to go one step further and change it to cost utility. I've still got the same two drugs. I need to put the number of quality adjusted life years gained on the bottom. So here's my 60% of patients and I'm going to tell you that these patients are going to live 10 years but they're only going to be at 70% quality of life. And I would have to measure this, I can't just make it up like this. All right. so they're going to have 4.2 QALYs. And my drug B, they're going to live longer 15 years but their quality of life is going to be a little bit less. But they're going to end up with 7.2 QALYs. So if I take my dollar amount over my QALYs it ends up that drug B is costing me a little bit less per quality adjusted life year. And still left with the question, what's a good value? I don't know whether 17's good, 19's good. A benchmark that's used is $50 to $100,000 per quality adjusted life year is kind of a good deal. It's where most people would think okay, that's a good use of our resources as a society. There are actual tables in different countries would use cutoffs. And say no we are not going to reimburse for that because it was a $150000 per quality adjusted life year. We don't do that in the US as of now.