Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively.

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En provenance du cours de Duke University

Bioelectricity: A Quantitative Approach

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Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively.

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Propagation

this week we will examine how action potentials in one region normally produce action potentials in adjacent regions, so that there is a sequence of action potentials, an excitation wave. the learning objectives for this week are: (1) Identify the differences between the propagation pattern following sub-threshold versus threshold stimuli; (2) Compute the changes in transmembrane potentials and currents from one time to a short time laterIdentify the outcome of stimulating a fiber at both ends; (3) Quantify the interval after propagation following one stimulus to the time when there will be another excitation wave following a 2nd stimulus; (4) Explain why "propagation" is different from "movement".

- Dr. Roger BarrAnderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics

Biomedical Engineering, Pediatrics

So hello again.

This is Roger Cokebar for

the bioelectricity course, we are now to section six, propagation.

Yes, this is where we've been trying to go.

We've put together all the pieces, discussed all the details, and

now we get to roll our trains.

All in the bioelectric sense, we need to,

we get to stimulate the tissue and watch propagation occur.

We'll talk about propagation in more than one way.

In the first part, we'll talk about propagation.

Looking at it in time and looking at it in space.

If you look at the train in the picture, you could imagine the train stopped on

the track and you look at it from the front to the back.

Or then again, if the train is moving, you can imagine standing at one point.

And just watching it come back, whatever's in front of you.

Looking at it in space and looking at it in time.

Thereafter, we'll talk about propagation and some of its details.

What the currents are and it's velocity, how fast it goes from place to place.

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