À propos de ce cours
4.7
41 notes
6 avis
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100 % en ligne

Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles

Dates limites flexibles

Réinitialisez les dates limites selon votre disponibilité.
Niveau intermédiaire

Niveau intermédiaire

Heures pour terminer

Approx. 19 heures pour terminer

Recommandé : 6 weeks of study, 3-5 hours a week...
Langues disponibles

Anglais

Sous-titres : Anglais
100 % en ligne

100 % en ligne

Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Dates limites flexibles

Dates limites flexibles

Réinitialisez les dates limites selon votre disponibilité.
Niveau intermédiaire

Niveau intermédiaire

Heures pour terminer

Approx. 19 heures pour terminer

Recommandé : 6 weeks of study, 3-5 hours a week...
Langues disponibles

Anglais

Sous-titres : Anglais

Programme du cours : ce que vous apprendrez dans ce cours

Semaine
1
Heures pour terminer
3 heures pour terminer

Introduction. Human genome

This week you will learn about human genome organisation. This week is very important as all this knowledge will form a basis for all of the subsequent weeks of the course. Michel Georges will tell you about the structural organisation of the human genome, the mechanisms contributing to the genome variability, the main types of genetic variation (SNPs, CNVs, aneuploidy, etc.), and differences between alleles and genotypes. You will also learn the techniques used to detect different types of variations in human genome and you will find out how we can follow the inheritance of genetic material through generations. ...
Reading
7 vidéos (Total 54 min), 9 lectures, 9 quiz
Video7 vidéos
Course Introduction1 min
Anatomy of the Human Genome13 min
Identifying Functionally Important Elements in the Human Reference Genome12 min
Genetic Polymorphism11 min
Interrogating Genetic Variation10 min
Week 1 Conclusion2 min
Reading9 lectures
Meet your Educators and Fellow Learners10 min
Course Navigation10 min
Typos in videos10 min
Recommended Pre-reading10 min
The Human Genome Project30 min
Recommended Pre-reading10 min
Recommended Pre-reading10 min
Recommended Pre-reading10 min
Glossary Week 110 min
Quiz9 exercices pour s'entraîner
Pre-lecture Questions6 min
Practice Quiz2 min
Pre-lecture Questions4 min
Practice Quiz2 min
Pre-lecture Questions4 min
Practice Quiz4 min
Pre-lecture Questions6 min
Practice Quiz2 min
Introduction. Human Genome8 min
Semaine
2
Heures pour terminer
4 heures pour terminer

Populational genetics

During this week, Yurii Aulchenko will teach you the basics of population and quantitative genetics. Population genetics is a branch of genetics that deals with genetic variation among individuals in a population. "Nothing in Biology Makes Sense Except in the Light of Evolution" is a quotation from a 1973 essay by the evolutionary biologist Theodosius Dobzhansky. The fundamental importance of population genetics lies in the insights it provides into the mechanisms of evolution, thus allowing geneticists to better understand the drivers behind the organization and functioning of human genomes. You will learn about such phenomena as population structure, selection and genetic drift. You will also learn about quantitative genetics, which studies how the genes and environment control variations in complex phenotypes....
Reading
7 vidéos (Total 59 min), 13 lectures, 13 quiz
Video7 vidéos
Hardy-Weinberg Equilibrium8 min
Linkage Disequilibrium8 min
Natural Selection11 min
Genetic Drift9 min
Genetic Structure12 min
Week 2 Conclusion2 min
Reading13 lectures
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Glossary Week 210 min
Quiz13 exercices pour s'entraîner
Pre-lecture Questions4 min
Practice Quiz4 min
Pre-lecture Questions6 min
Practice Quiz4 min
Pre-lecture Questions4 min
Practice Quiz4 min
Pre-lecture Questions4 min
Practice Quiz2 min
Pre-lecture Questions4 min
Practice Quiz4 min
Pre-lecture Questions2 min
Practice Quiz4 min
Populational Genetics14 min
Semaine
3
Heures pour terminer
3 heures pour terminer

Mendelian disorders

Mendelian or monogenic disorders are the kind of genetic disorders in humans that arise from a mutation in a single gene. These disorders run in families and can be autosomal or sex-linked depending whether the affected gene is located on autosomes or sex chromosomes, and they can also be dominant or recessive depending if one or two alleles are necessary to develop the disorder. The name “Mendelian” is used because these diseases follow simple monogenic patterns of inheritance, similar to these first studied by Gregor Mendel in pea plants. There are an estimated 8000 rare Mendelian diseases. Although each of them are very rare, collectively they affect millions of individuals world-wide. How can we find the variants and genes that are responsible for the development of these diseases? You will learn about “linkage analysis” – a technique that has been previously used for this purpose. You will also learn about Next-generation sequencing (NGS) technologies that have revolutionized the studies of Mendelian diseases in recent years. ...
Reading
6 vidéos (Total 51 min), 10 lectures, 11 quiz
Video6 vidéos
Linkage Analysis. Family Studies11 min
NGS for Studying Monogenic Disorders — Part I7 min
NGS for Studying Monogenic Disorders — Part II10 min
NGS for Studying Monogenic Disorders — Part III11 min
Week 3 Conclusion1 min
Reading10 lectures
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Mendelian disorders: discussion10 min
Glossary Week 310 min
Quiz11 exercices pour s'entraîner
Pre-lecture Questions2 min
Practice Quiz2 min
Pre-lecture Questions2 min
Practice Quiz2 min
Pre-lecture Questions2 min
Practice Quiz2 min
Pre-lecture Questions4 min
Practice Quiz2 min
Pre-lecture Questions2 min
Practice Quiz2 min
Mendelian Disorders10 min
Semaine
4
Heures pour terminer
6 heures pour terminer

Complex disorders

In contrast to Mendelian disorders that are controlled by a mutation in one gene, the multifactorial disorders are more complex, thus the name. These disorders are affected by an interplay of many genetic and environmental factors and also by a chance. Most of the human disorders, including prevalent types of diabetes, cardiovascular diseases, different cancers, are of such type. Although these disorders often cluster in families, they do not segregate in ways that are consistent with simple Mendelian inheritance. The methods used to find variants responsible for Mendelian disorders are not applicable for complex ones. Genome-wide association studies, or “GWAS” is a current method of choice to pinpoint the genetic variation predisposing to complex disorders. Yurii Aulchenko together with Lennart Karssen will tell you about this method and discuss its advantages and limitations. ...
Reading
10 vidéos (Total 88 min), 18 lectures, 19 quiz
Video10 vidéos
Introduction to Genome-Wide Association Studies. Historical Overview12 min
GWAS Nowadays. Imputations10 min
4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS11 min
4.5. Population Stratification and its Consequences10 min
4.6. Analysis of Genetically Structured Populations9 min
4.7. Meta-analysis of GWAS Results: Theory and Background6 min
4.8. Quality Control of GWAS Array Data10 min
4.9. Meta-analysis of GWAS Results: Practical Details8 min
Week 4 Conclusion2 min
Reading18 lectures
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Recommended Pre-reading10 min
Additional Materials10 min
Additional Materials10 min
Glossary Week 410 min
Quiz19 exercices pour s'entraîner
Pre-lecture Questions4 min
Practice Quiz4 min
Pre-lecture Questions2 min
Practice Quiz6 min
Pre-lecture Questions2 min
Practice Quiz2 min
Pre-lecture Questions4 min
Post-lecture Questions4 min
Pre-lecture Questions2 min
Post-lecture Questions4 min
Pre-lecture Questions4 min
Post-lecture Questions6 min
Pre-lecture Questions2 min
Post-lecture Questions4 min
Pre-lecture Questions2 min
Post-lecture Questions2 min
Pre-lecture Questions2 min
Quiz4 min
Complex disorders26 min
4.7
6 avisChevron Right
Promotion de carrière

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Meilleurs avis

par FLSep 27th 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

par JQDec 30th 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

Enseignants

Avatar

Marianna Bevova

PhD, Director of GIGA Doctoral School
University of Liège (GIGA)
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Michel Georges

PhD, Professor, GIGA Research Director
University of Liège
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Gert Matthijs

PhD, Professor
Center for Human Genetics, University of Leuven
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Lennart Karssen

PhD, Owner and Chief Computational Scientist
PolyOmica
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Natalia Aulchenko

M.Sc., Project manager
Theoretical and Applied Functional Genomics Laboratory
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Yakov Tsepilov

PhD, Senior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Sodbo Sharapov

M.Sc, Junior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Alexander Tashkeev

Skolkovo Institute of Science and Technology (Skoltech), Junior Researcher
Laboratory of Computational and Structural Transcriptomics
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Yurii Aulchenko

PhD, Professor, Head of Theoretical and Applied Functional Genomics Laboratory
Theoretical and Applied Functional Genomics Laboratory

À propos de Novosibirsk State University

Novosibirsk State University (NSU) is a research university located in Novosibirsk Akademgorodok, the world-famous scientific center in Siberia. 80% of NSU teachers are active researchers affiliated with the Russian Academy of Sciences; therefore education is closely linked to world-class science: our students get first-hand knowledge about scientific discoveries before they are published. Nearly 6000 students (including international students from 37 countries) are enrolled at undergraduate and graduate programs offered by 13 departments. The leading areas of NSU expertise are natural sciences, life sciences, physics, math, IT, and more....

Foire Aux Questions

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