À propos de ce cours
4.5
33 ratings
11 reviews
Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively....
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Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Calendar

Dates limites flexibles

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Intermediate Level

Niveau intermédiaire

Clock

Recommandé : 6 hours/week

Approx. 22 heures pour terminer
Comment Dots

English

Sous-titres : English
Globe

Cours en ligne à 100 %

Commencez dès maintenant et apprenez aux horaires qui vous conviennent.
Calendar

Dates limites flexibles

Réinitialisez les dates limites selon votre disponibilité.
Intermediate Level

Niveau intermédiaire

Clock

Recommandé : 6 hours/week

Approx. 22 heures pour terminer
Comment Dots

English

Sous-titres : English

Programme du cours : ce que vous apprendrez dans ce cours

1

Section
Clock
3 heures pour terminer

Electricity in Solutions

This week's theme focuses on the foundations of bioelectricity including electricity in solutions. The learning objectives for this week are: (1) Explain the conflict between Galvani and Volta; (2) Interpret the polarity of Vm in terms of voltages inside as compared to outside cells; (3) Interpret the polarity of Im in terms of current flow into or out of a cell.; (4) Determine the energy in Joules of an ordinary battery, given its specifications; (5) State the “big 5” electrical field variables (potentials, field, force, current, sources) and be able to compute potentials from sources (the basis of extracellular bioelectric measurements such as the electrocardiogram) or find sources from potentials....
Reading
12 vidéos (Total 66 min), 5 lectures, 2 quiz
Video12 vidéos
What is the Question5 min
About Bioelectricity5 min
Major Sections of the Course5 min
Rectification of Names10 min
Ions in Solution6 min
Core-Conductor Model of a Nerve Fiber9 min
Potential and Voltages in the Fiber5 min
Axial Currents in the Fiber5 min
Membrane Resistance3 min
Membrane Current, Failure & Mystery3 min
Week 1 in Review4 min
Reading5 lectures
Welcome to the Course min
Assessments, Grading and Certificates10 min
Course Lecture Slides10 min
Discussion Forums10 min
Reference Text10 min
Quiz2 exercices pour s'entraîner
Quiz 1A10 min
Quiz 1B16 min

2

Section
Clock
2 heures pour terminer

Energy into Voltage

This week we will examine energy, by which pumps and channels allow membranes to "charge their batteries" and thereby have a non-zero voltage across their membranes at rest. The learning objectives for this week are: (1) Describe the function of the sodium-potassium pump; (2) State from memory an approximate value for RT/F; (3) Be able to find the equilibrium potential from ionic concentrations and relative permeabilities; (4) Explain the mechanism by which membranes use salt water to create negative or positive trans-membrane voltages....
Reading
12 vidéos (Total 76 min), 2 quiz
Video12 vidéos
A Membrane Patch; the Idea of It7 min
Energy as Trans-membrane Voltage Vm3 min
Sodium-potassium Pumps4 min
Ionic equilibrium13 min
Battery lifetime5 min
Problem session 14 min
Membrane Resistance Rm9 min
Membrane capacitance Cm4 min
Why is Cm so big?7 min
Problem session, R and C8 min
Week 2 summary5 min
Quiz2 exercices pour s'entraîner
Quiz 2A20 min
Quiz 2B12 min

3

Section
Clock
2 heures pour terminer

Passive and Active Resonses, Channels

This week we'll be discussing channels and the remarkable experimental findings on how membranes allow ions to pass through specialized pores in the membrane wall. The learning objectives for this week are: (1) Describe the passive as compared to active responses to stimulation; (2) Describe the opening and closing of a channel in terms of probabilities; (3) Given the rate constants alpha and beta at a fixed Vm, determine the channel probabilities; (4) Compute how the channel probabilities change when voltage Vm changes....
Reading
12 vidéos (Total 82 min), 1 lecture, 3 quiz
Video12 vidéos
Why are passive and active so different?3 min
The simulation set-up9 min
The passive simulation11 min
The active simulation11 min
Where does the active response come from?8 min
Problem session, passive v active6 min
Channels: Experimental isolation of a channel7 min
Channels: Observed currents, voltage step4 min
Channels: Probability of being open6 min
Problem session, Channel probabilities8 min
Week 3 Conclusions4 min
Reading1 lecture
Alpha Beta Programming Assignment Instructions10 min
Quiz3 exercices pour s'entraîner
Quiz 3A12 min
Quiz 3B18 min
Alpha Beta Programming Assignment24 min

4

Section
Clock
3 heures pour terminer

Hodgkin-Huxley Membrane Models

This week we will examine the Hodgkin-Huxley model, the Nobel-prize winning set of ideas describing how membranes generate action potentials by sequentially allowing ions of sodium and potassium to flow. The learning objectives for this week are: (1) Describe the purpose of each of the 4 model levels 1. alpha/beta, 2. probabilities, 3. ionic currents and 4. trans-membrane voltage; (2) Estimate changes in each probability over a small interval $$\Delta t$$; (3) Compute the ionic current of potassium, sodium, and chloride from the state variables; (4) Estimate the change in trans-membrane potential over a short interval $$\Delta t$$; (5) State which ionic current is dominant during different phases of the action potential -- excitation, plateau, recovery....
Reading
12 vidéos (Total 95 min), 1 lecture, 3 quiz
Video12 vidéos
What is the Problem8 min
HH replacement for Rm5 min
The equation for each pathway10 min
Changes in n, m, h11 min
Equations for alphas and betas18 min
Problem session, I_Na9 min
Putting it all together6 min
Changes in n, m, h, and Vm5 min
Numerical calculations, time and space6 min
Problem session, a Vm step4 min
Week 4 conclusions5 min
Reading1 lecture
Action Potential Programming Assignment10 min
Quiz3 exercices pour s'entraîner
Quiz 4A16 min
Quiz 4B20 min
Action Potential Programming Assignment18 min
4.5

Meilleurs avis

par JRSep 25th 2016

Very clear expectations, and the lectures were spaced out nicely to cover material while not being overwhelming. Additionally, the analogies used to convey the principles were clever and helpful!

par AJJan 15th 2018

Interesting class which derived mathematical models that were, and are still used, to describe nerves.

Enseignant

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

À propos de Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

Foire Aux Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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