Behavioral genetic methodologies from twin and adoption studies through DNA analysis will be described and applied to address longstanding questions about the origins of individual differences in behavioral traits.
Introduction to Human Behavioral Genetics
proposé par
University of Minnesota
À propos de ce cours
4.8
155 notes
Compétences que vous acquerrez
PsychologyGenetic CounselingGeneticsBehavioral Medicine
Programme du cours : ce que vous apprendrez dans ce cours
Semaine
11
Unit # 1: Course Introduction and OverviewOverview: Unit # 1 provides an overview to the field of human behavioral genetics and to this course. We will begin by discussing the early history of the field and how behavioral genetic research influenced and was influenced by the eugenics movement. Once this historical context has been established, we will define the field of behavioral genetics and use this definition to provide an overview of the course. This week’s lectures will end with two case studies that illustrate the importance of behavioral genetic approaches. The first is the famous John/Joan case, where one member of a monozygotic twin pair was raised as a boy and the other as a girl. The second is the human genetic disorder Phenylketonuria (PKU), which has been recognized as a paradigm of human genetic disease since its discovery in 1934.Unit Objectives: At the end of this unit you should know• The history of the founding of the field of behavioral genetics• What the eugenics movement was and how it impacted psychology and behavioral genetics• What the field of behavioral genetics covers• How the John/Joan case represented the extreme of the “Blank Slate” mentality within psychology• Why Phenylketonuria is considered a public health success and model of human genetic diseaseLecture Modules:A. The Nature-Nurture Debate and Founding of Behavioral GeneticsB. The Eugenics MovementC. What is Behavioral GeneticsD. The John/Joan CaseE. Phenylketonuria (PKU) F. Huntington Disease (Supplemental)
7 vidéos (Total 110 min), 3 lectures, 1 quiz
7 vidéos
1B: The Eugenics Movement 15 min
1C: What is Behavioral Genetics? 7 min
1D: The John/Joan Case 17 min
1E: Phenylketonuria (PKU) 15 min
1F: Huntington Disease - Supplementary 18 min
Unit 1 Office Hours Video 20 min
3 lectures
Required Reading #1: Genetics and Human Behaviour: the Ethical Context10 min
Required Reading #2: Taboo Genetics10 min
Additional resources for Topic #110 min
1 exercice pour s'entraîner
Unit 1 Quiz12 min
Semaine
22
In Unit #2 the twin study method will be introduced and general findings from twin studies in psychology and psychiatry will be reviewed. The two types of twins, monozygotic (MZ) and dizygotic (DZ), will be described and methods for assessing their similarity will be given. We will also look critically at the limitations of the twin study method and discuss alternative research designs, including adoption studies and the study of reared-apart twins. The importance of convergent evidence from multiple research designs will be emphasized.
8 vidéos (Total 144 min), 2 lectures, 1 quiz
8 vidéos
2B: How to Assess Twin Similarity 14 min
2C: Findings from Twin Studies 16 min
2D: Are Twin Studies Valid? 19 min
2E: Adoption Studies: Not by Twins Alone 13 min
2F: Minnesota Study of Twins Reared Apart (MISTRA) 18 min
2G: Conversation with Tom Bouchard - Supplementary 19 min
Unit 2 Office Hours Video 26 min
2 lectures
Required reading: Minnesota Study of Twins Reared Apart10 min
Additional resources for Topic #210 min
1 exercice pour s'entraîner
Unit 2 Quiz14 min
Semaine
33
Some of the most contentious issues in behavioral genetics surround the concept of heritability – Is it a meaningful statistic? Can it be accurately estimated in studies on humans? How should it be interpreted? In this unit we will discuss what is meant by heritability and describe some simple biometric (i.e., quantitative genetic) methods used for it estimation. The unit begins with a review of basic Mendelian inheritance and the introduction of some genetic terminology we will begin to use in the course. The ACE model of quantitative inheritance is described and we will discuss how this model is used to analyze twin data. Finally, the important concept of gene-environment interaction is formally introduced. Beginning this week with quantitative genetics and continuing next week with molecular genetics we will be jumping head first into the thicket of human genetic methodology. For some, this material may be more challenging than that which we covered in the first two weeks of this course. These weeks will, however, provide the foundation we will need to investigate in depth behavioral genetic research on schizophrenia and intelligence in weeks 5 and 6. Please make sure to post questions you have to the discussion forums and especially to the office hours forum.
7 vidéos (Total 138 min), 2 lectures, 1 quiz
7 vidéos
3B: Galtonian Inheritance (aka Quantitative Genetics) 19 min
3C: How is Heritability Estimated? 22 min
3D: What Heritability Is and What It Is Not 12 min
3E: Gene-Environment Interaction 21 min
3F: Multivariate Approaches - Supplementary 11 min
Unit 3 Office Hours Video 30 min
2 lectures
Required reading: The Human Genome10 min
Additional resources Topic #310 min
1 exercice pour s'entraîner
Unit 3 Quiz10 min
Semaine
44
The Human Genome Project (HGP) was begun in 1990 and declared complete in 2003. It has revolutionized our understanding of genetics and will ultimately revolutionize medical practice. In my opinion, every educated citizen should know some basic findings from the HGP. This week’s lectures provide an introduction to molecular biology and the HGP. We will cover topics such as: What is DNA? What is a gene and how are genes structured? In what ways can human genomes differ? What is epigenetics and why do some researchers believe it is very important for understanding behavior? As in previous lectures, I will illustrate some of the basic human genetic phenomena through case studies, in this case ranging from calico cats to the human genetic disorders of Angelman and Prader-Willi syndromes.
This week’s lectures continue what we began last week: laying the foundation of genetic concepts and processes we will need to consider in some depth genetic research on schizophrenia and intelligence. Some participants in this course already have an extensive background in basic genetics and so will be very knowledgeable about material covered in the initial modules. But I think even these participants will have something to learn when we get to the later modules in the unit covering, e.g., Williams Syndrome, Prader-Willi Syndrome and Angelman Syndrome. For those with a more limited background in genetics, I recognize that the terminology introduced this week may at first seem a bit daunting. But if you stick with it, terms such as SNPs, methylation, exon, copy number variants, etc. which seem foreign now will become consolidated in your vocabulary through repeated use throughout the remaining lectures in this course.
There are several learning aids I would encourage you to use. First, we have created a Glossay, which you can link to off the navigation bar on the course website. Second, the Discussion Forums are a wonderful source of help. Other participants can be very helpful in answering your questions and a post in the Office Hours thread will be reviewed by us for response in the weekly office hour video. Finally, we give again online genetics education links in the Other Resources section below.
10 vidéos (Total 159 min), 3 lectures, 1 quiz
10 vidéos
4A: DNA 11 min
4B: What Is a Gene? 9 min
4C: Three Surprising Findings From the Human Genome Project 13 min
4D: Genetic Variation 20 min
4E: Williams Syndrome 11 min
4F: The X Chromosome 7 min
4G: Prader-Willi & Angelman Syndromes 13 min
4H: Genetic Regulation and Epigenetics 21 min
4I: Epigenetic Inheritance - Supplementary 20 min
Unit 4 Office Hours Video 30 min
3 lectures
Required reading #1: Genomic Medicine10 min
Required reading #2: Epigenetics10 min
Additional resources Topic #410 min
1 exercice pour s'entraîner
Unit 4 Quiz 18 min
4.8
49 avis50%
a commencé une nouvelle carrière après avoir terminé ces cours
40%
a bénéficié d'un avantage concret dans sa carrière grâce à ce cours
33%
a obtenu une augmentation de salaire ou une promotion
Meilleurs avis
par MM•Sep 13th 2018
It is an amazing course. After this course, my perspective towards genetics and psychology have changed. Many thanks to Professor Matt McGue. He has been one amazing guide, for the subject.
par DS•Jun 6th 2017
The discussion board was not very active in this session/iteration, but the coarse was well put together, balanced and interesting. Hence, 5 stars!
Enseignant
Matt McGue
Regents ProfessorPsychology
À propos de University of Minnesota
The University of Minnesota is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation’s most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.
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